# MECHANISMS OF B CELL TRANSFORMATION AND LYMPHOMOGENESIS

> **NIH NIH R01** · WISTAR INSTITUTE · 1989 · $160,461

## Abstract

The long-term goal of this project remains an understanding of
the mechanisms that promote transformation and progression of B
cell lymphomas.  To this end, we have focused, and will continue
to focus on avian Lymphoid Leukosis (LL) as a model system.
Like other lymphomagenic systems, the natural history of LL has
been characterized as a multistage process of transformation that
involves pre-neoplastic, neoplastic and metastaic stages; however
the basis for progression from one stage to the next is poorly
understood.  We will take advantage of expertise recently
developed in our laboratory to isolate individual hyperplastic
follicles that will now permit analysis of cells at all three stages
of LL tumor development.  We propose to analyze factors
intrinsic to the B cell that are likely to be integral to the
transformation process, i.e., provival composition, orientation and
site of integration, and single or multiple proto-oncogene
activation, to determine their role in the transformation and
progression of the LL tumors.  We will also examine the
relationship between the state of cellular
differentiation/maturation, and the susceptibility of B cells to
transformation and the potential of transformed B cells to
metastasize.  Finally, we will analyse the effects of the selective
pressures caused by immune mechanisms on the progression of
cells at each stage of lymphomagenesis.  These experiments
should provide insight into the mechanisms of neoplastic
transformation and tumor progression as well as the processes of
normal B cell development and thereby a context for the
interpretation of the neoplastic changes.

## Key facts

- **NIH application ID:** 3177608
- **Project number:** 5R01CA039000-05
- **Recipient organization:** WISTAR INSTITUTE
- **SAM.gov UEI:** DW1XZMGNFBL4
- **Principal Investigator:** DONALD L EWERT
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $160,461
- **Award type:** 5
- **Project period:** 1986-09-30 → 1991-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3177608

## Citation

> US National Institutes of Health, RePORTER application 3177608, MECHANISMS OF B CELL TRANSFORMATION AND LYMPHOMOGENESIS (5R01CA039000-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3177608. Licensed CC0.

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