# GROWTH REGULATION OF POLYAMINE SYNTHESIS

> **NIH NIH R01** · UNIVERSITY OF WASHINGTON · 1989 · $190,177

## Abstract

The rates of synthesis of the polyamines (spermidine and
spermine) and their metabolic precursor putrescine are increased
during the proliferative response of mammalian cells and
elevated levels of these compounds are necessary for optimal
cell growth.  Two key enzymes of polyamine biosynthesis,
ornithine decarboxylase (ODC) and S-adenosylmethionine
decarboxylase (SDC), are regulated during this process.  We have
shown that the synthesis of these two proteins is regulated by
both the levels and efficiency of translation of their respective
mRNAs.  In this application we propose to define the structure
of the SDC gene and the mRNAs that are synthesized from it.
The level of SDC mRNA is regulated post-transcriptionally and
the mechanism of this will be studied.  In addition, we will
further characterize the mechanism of the control of translation
of both ODC and SDC mRNAs through the use of in vitro
mutagenesis and gene transfer techniques.

## Key facts

- **NIH application ID:** 3177751
- **Project number:** 5R01CA039053-06
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **SAM.gov UEI:** HD1WMN6945W6
- **Principal Investigator:** DAVID R MORRIS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $190,177
- **Award type:** 5
- **Project period:** 1984-07-01 → 1992-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3177751

## Citation

> US National Institutes of Health, RePORTER application 3177751, GROWTH REGULATION OF POLYAMINE SYNTHESIS (5R01CA039053-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3177751. Licensed CC0.

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