# RADIATION & HYPERTHERMIA SEQUENCES FOR THERAPEUTIC GAIN

> **NIH NIH R01** · UNIVERSITY OF CINCINNATI · 1987 · $193,346

## Abstract

To best use hyperthermia with radiotherapy in the treatment of cancer it is
essential to determine optimal methods for combining these treatments and
to identify which patients will derive the greatest therapeutic benefit.
The purpose of this study is to evaluate the efficacy of local tumor
control and quantitate the magnitude and characteristics of acute and late
normal tissue changes when curative intent radiotherapy is combined with
therapeutic hyperthermia in a prospective randomized trial using
spontaneous tumors in companion animals (canine and feline) as a model
system for human cancer therapy.

Dogs and cats with spontaneous tumors referred to us by local veterinarians
will be stratified by histology and randomly assigned to one of three
protocol groups.  Each group will receive thrice weekly tumor radiation
doses of 3.5 Gy to a total of 14 treatments.  Two of the groups will, in
addition, receive 5 weekly hyperthermia treatments targeted to 44 degrees C
for 30 minutes where radiation will precede hyperthermia either immediately
or 4-5 hours post-irradiation.  All treatments will be administered under
general anesthesia.  Radiotherapy treatments of standardized anatomic zones
containing the tumor will be administered using the radiotherapy modality
(60 Co or linac photons) giving the most uniform dose distribution.
Hyperthermia treatments will be administered with a Clinitherm Mark VI
clinical microwave hyperthermia unit using either external or interstitial
antennas.  Treatment temperatures will be monitored within the tumor and
surrounding normal tissue by up to 12 interstitial fiberoptic sensors.
Each treated animal will be followed for 2 years to quantitate:  the degree
of tumor response, the frequency of tumor recurrence, the characteristics,
frequencies, and magnitudes of acute and late changes within treated normal
tissues and within the tumor bed, and the time following treatment
commencement when these effects are observed.  These results will be
analyzed by appropriate statistical methods in a manner designed to
demonstrate how the relationships between the treatment administered, and
the acute and late normal tissue changes and the tumor response and
recurrence rates are affected by the major identifiable variables including
tumor histology, volume, anatomic site and thermal dose.  This analysis
will demonstrate those changes in acute and late normal tissue
complications that occur when heat is combined with radiation, as well as
to help establish prognostic factors which can be used to plan appropriate
combined treatments for a variety of clinical cancer management situations.

## Key facts

- **NIH application ID:** 3178147
- **Project number:** 5R01CA039314-02
- **Recipient organization:** UNIVERSITY OF CINCINNATI
- **SAM.gov UEI:** DZ4YCZ3QSPR5
- **Principal Investigator:** DAVID L DENMAN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $193,346
- **Award type:** 5
- **Project period:** 1986-05-01 → 1989-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3178147

## Citation

> US National Institutes of Health, RePORTER application 3178147, RADIATION & HYPERTHERMIA SEQUENCES FOR THERAPEUTIC GAIN (5R01CA039314-02). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3178147. Licensed CC0.

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