# ANTHRACYCLINES FROM ISOQUINOLINES

> **NIH NIH R01** · HUNTER COLLEGE · 1987 · $120,436

## Abstract

Anthracycline antibiotics such as daunomycin and adriamycin are clinically
important antitumor drugs.  Other members of the anthracycline family
include 7-con-O-methyl-nogarol, also an antitumor drug, and aquayamycin.
Aquayamycin and its glycosides are powerful inhibitors of hydroxylase
enzymes including proline hydroxylase, dopamine beta-hydroxylase and
tyrosine hydroxylase.  A new methodology for the synthesis of anthracycline
structures has been uncovered in our laboratory.  The method will permit
chiral and convergent preparations of the antibiotics listed above as well
as their analogs.

## Key facts

- **NIH application ID:** 3178206
- **Project number:** 5R01CA039351-03
- **Recipient organization:** HUNTER COLLEGE
- **SAM.gov UEI:** EK93EZLLBSC4
- **Principal Investigator:** RICHARD W. FRANCK
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $120,436
- **Award type:** 5
- **Project period:** 1985-07-01 → 1989-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3178206

## Citation

> US National Institutes of Health, RePORTER application 3178206, ANTHRACYCLINES FROM ISOQUINOLINES (5R01CA039351-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3178206. Licensed CC0.

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