# ANTHRACYCLINES FROM ISOQUINOLINES

> **NIH NIH R01** · HUNTER COLLEGE · 1992 · $155,712

## Abstract

The proposed research will develop the cycloaddition of the isoquinolinium
salts as a method for the synthesis of two classes of anthracyclines with
antitumor and anti HIV activity.  One class, the sakiomysins and related
compounds are characterized by their angular framework which is highly
oxidized.  Sakiomycin A has been shown to inhibit the proliferation of HIV
(AIDS) virus, presumably by inhibition of reverse transcriptose.  The
second class, the C-glycoside analogs of the clinically important
anthracyclines, are not available in nature.  The biological activity of
the C-glycosides will provide important information about the requirements
for cytotoxicity and cardiotoxicity of the parent compounds.

## Key facts

- **NIH application ID:** 3178208
- **Project number:** 5R01CA039351-06
- **Recipient organization:** HUNTER COLLEGE
- **SAM.gov UEI:** EK93EZLLBSC4
- **Principal Investigator:** RICHARD W. FRANCK
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $155,712
- **Award type:** 5
- **Project period:** 1985-07-01 → 1994-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3178208

## Citation

> US National Institutes of Health, RePORTER application 3178208, ANTHRACYCLINES FROM ISOQUINOLINES (5R01CA039351-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3178208. Licensed CC0.

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