# STUDIES OF A HUMAN MONOCYTE CYTOTOXICITY-INDUCING FACTOR

> **NIH NIH R01** · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 1991 · $122,307

## Abstract

The goals of this grant are to continue the characterization of a novel
monocyte activating factor (MAF) produced by the T-cell hybridoma FtF3
(ATCC HB 9713) developed in this laboratory.  The specific aims are:

1.  Sequence both MAF proteins

2.  Prepare synthetic peptides to confirm sequence/activity relationship,
function, and for production of monoclonal antibodies.

3.  Production of monoclonal antibodies.

4.  Make cDNA and/or oligonucleotide probes, and isolated the gene.

Identification of these factors are important in the understanding of the
immunology of lymphocyte/monocyte interactions, and may be of potential
clinical value in augmenting the immune response against tumors and
microorganisms.

## Key facts

- **NIH application ID:** 3178425
- **Project number:** 5R01CA039441-05
- **Recipient organization:** UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- **SAM.gov UEI:** ZUFBNVZ587D4
- **Principal Investigator:** CLYDE M JONES
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $122,307
- **Award type:** 5
- **Project period:** 1985-05-01 → 1993-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3178425

## Citation

> US National Institutes of Health, RePORTER application 3178425, STUDIES OF A HUMAN MONOCYTE CYTOTOXICITY-INDUCING FACTOR (5R01CA039441-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3178425. Licensed CC0.

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