# HYPERTHERMIA BY SURGICALLY PLACED FERROMAGNETIC IMPLANTS

> **NIH NIH R01** · UNIVERSITY OF ARIZONA · 1989 · $427,175

## Abstract

The purpose of this research is to develop and evaluate the use of
surgically implanted, thermally regulating ferromagnetic implants
for inducing hyperthermia in tumors.  The research can be grouped
into two broad categories:  1.  The clinical evaluation of the
existing seeds in a number of clinical sites.  This clinical work
focusses on Phase I type trials where efficacy of heating is the
primary endpoint and the development of clinical techniques,
procedures and possibly instrumentation is the principal research
process. We propose to take advantage of the clinical facilities
of the University of Arizona, the University of California at San
Francisco, and the City of Hope Medical Center.  2. The further
development of the method by introducing better ferromagnetic
materials and seed configurations and by introducing a permanently
implanted version of the seeds.  Both of these categories of
research are bolstered by the development of better instrumentation
and methods of characterizing the implants and by the development
of quality assurance tests and procedures.  It is anticipated that
randomized clinical trials will be developed and introduced
subsequently in later years of the grant, but the detailed
specification of these are premature until experience is obtained
in Phase I.

## Key facts

- **NIH application ID:** 3178481
- **Project number:** 5R01CA039468-05
- **Recipient organization:** UNIVERSITY OF ARIZONA
- **SAM.gov UEI:** ED44Y3W6P7B9
- **Principal Investigator:** THOMAS C CETAS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $427,175
- **Award type:** 5
- **Project period:** 1985-07-01 → 1991-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3178481

## Citation

> US National Institutes of Health, RePORTER application 3178481, HYPERTHERMIA BY SURGICALLY PLACED FERROMAGNETIC IMPLANTS (5R01CA039468-05). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3178481. Licensed CC0.

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