# EPIDEMIOLOGIC STUDY OF MULTIPLE PRIMARY BREAST CANCER

> **NIH NIH R01** · YALE UNIVERSITY · 1987 · $224,624

## Abstract

A population-based case-control epidemiologic study will be conducted to
investigate risk factors associated with the incidence of second primary
breast cancer.  Incident cases of second primary breast cancer will be
identified through the Connecticut Tumor Registry and review of pathology
records at Connecticut hospitals.  The cases, who will number approximately
360, will be compared to an equal number of controls selected randomly from
women who have developed a first primary but not a second and who are alive
at the time that the second primaries develop in the cases.  Interviews
will be conducted using a structured questionnaire administered in person
by trained interviewers.  The questionnaire will include items covering
reproductive history, family history of cancer, use of estrogens,
socio-demographic factors, and relevant medical conditions and procedures.
Medical information concerning the characteristics of the first primary
cancers of both cases and controls will be obtained from hospital records.
This information will include stage of disease, hormone receptor levels,
size of tumor, and type of treatment.  An independent pathologic review
will be conducted for distinguishing second primaries from metastases and
for classifying the histologic features of the first primary cancers in a
uniform manner.  Multiple logistic regression analysis will be performed in
order to assess the effects of each factor while taking all other factors
into account.  The results should permit improved prediction of which women
are at high risk for second primary breast cancer.  This information will
have important implications for clinical care and may help to elucidate
further the etiology of breast cancer in general.

## Key facts

- **NIH application ID:** 3178495
- **Project number:** 5R01CA039477-03
- **Recipient organization:** YALE UNIVERSITY
- **SAM.gov UEI:** FL6GV84CKN57
- **Principal Investigator:** WILLIAM D THOMPSON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $224,624
- **Award type:** 5
- **Project period:** 1985-04-01 → 1988-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3178495

## Citation

> US National Institutes of Health, RePORTER application 3178495, EPIDEMIOLOGIC STUDY OF MULTIPLE PRIMARY BREAST CANCER (5R01CA039477-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3178495. Licensed CC0.

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