# NEOPLASTIC MODULATION OF PROTEOGLYCAN METABOLISM

> **NIH NIH R01** · UNIVERSITY OF PENNSYLVANIA · 1987 · $133,473

## Abstract

Despite the growing evidence implicating proteoglycans in the control of
cell proliferation and differentiation, little is known about the factors
that control their metabolism in neoplasia or the mechanisms through which
these macromolecules may influence neoplastic growth.  This project is
based upon our previous in vivo observation that proteoglycans are markedly
increased in human colon carcinoma, and that the connective tissue stroma
surrounding the neoplastic cells is the major site of synthesis and
accumulation of sulfated proteoglycans.  This research will study the
interaction between human neoplastic and mesenchymal cells in an in vitro
system using human colon carcinoma cells and the two major mesenchymal
cells of colon, i.e., colon fibroblasts and smooth muscle cells.  The
primary goal is to determine whether these tumor cells influence the levels
of proteoglycans synthesized by normal human colon fibroblasts and smooth
muscle cells in vitro, and to determine whether these effects reflect
alteration in the rates of synthesis and/or degradation of the various
proteoglycans in these two normal cell types.  Experiments will be
performed to analyze the biochemical and structural characteristics of the
proteoglycans synthesized by colon fibroblasts and smooth muscle cells when
cultured in the presence or absence of tumor metabolites.  We will
determine whether the postulated effects occur via a direct
neoplastic-mesenchymal cell interaction or via the release of diffusable
metabolites produced by the tumor cells.  Additional studies are planned to
investigate the nature of the modulation of proteoglycan metabolism and
whether this effect is coupled to a stimulation of cell proliferation.  (S)

## Key facts

- **NIH application ID:** 3178503
- **Project number:** 5R01CA039481-03
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **SAM.gov UEI:** GM1XX56LEP58
- **Principal Investigator:** RENATO V. IOZZO
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $133,473
- **Award type:** 5
- **Project period:** 1985-09-01 → 1988-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3178503

## Citation

> US National Institutes of Health, RePORTER application 3178503, NEOPLASTIC MODULATION OF PROTEOGLYCAN METABOLISM (5R01CA039481-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3178503. Licensed CC0.

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