# MONOCLONAL ANTIBODIES AGAINST LEUKEMIA

> **NIH NIH R01** · FRED HUTCHINSON CANCER RESEARCH CENTER · 1992 · $206,405

## Abstract

Our objective is to prepare monoclonal antibodies which recognize
the antigens expressed by normal or acute nonlymphocytic leukemic
(ANL) progenitor cells.  We will then use these antibodies to
isolate and characterize normal progenitor subpopulations and
determine if malignant progenitor cells can be separated from those
capable of normal hematopoiesis.

Our approach is based on our previous characterization of antigens
present on normal myeloid colony forming cells and their
precursors, including progenitors capable of establishing
hematopoiesis in vivo.  These antigenic markers were useful for
distinguishing leukemic colony-forming cells from normal colony-
forming cell precursors in some but not all patients with ANL.  An
important aspect of these studies was the use of a clonal marker
to discern the malignant versus normal origin of the separated stem
cell populations.

In the period of this proposal we will 1) prepare monoclonal
antibodies that recognize novel antigens on normal and malignant
progenitor cells, and define the biochemical nature of these
antigens.  We will then 2) use these antibodies to isolate and
characterize normal and malignant progenitors present in ANL
specimens that express a clonal marker.  This will include studies
to detect premalignant progenitors, and with patients in remission,
rare populations of clonally derived cells.  Selective depletion
of ANL progenitor cells or isolation of normal progenitors would
provide a rational basis for monoclonal antibody treatment of ANL.

## Key facts

- **NIH application ID:** 3178537
- **Project number:** 5R01CA039492-08
- **Recipient organization:** FRED HUTCHINSON CANCER RESEARCH CENTER
- **SAM.gov UEI:** HMSNCM57QNR5
- **Principal Investigator:** IRWIN D BERNSTEIN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $206,405
- **Award type:** 5
- **Project period:** 1985-08-01 → 1994-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3178537

## Citation

> US National Institutes of Health, RePORTER application 3178537, MONOCLONAL ANTIBODIES AGAINST LEUKEMIA (5R01CA039492-08). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3178537. Licensed CC0.

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