# INDUCTION OF GENE EXPRESSION BY CHEMICAL CARCINOGENS

> **NIH NIH R01** · ALBERT EINSTEIN COLLEGE OF MEDICINE · 1987 · $194,005

## Abstract

The environment is filled with compounds known to be either toxic or
carcinogenic.  It is therefore important to understand how organisms
respond to these agents at the cellular and molecular level.  It is known
that induction of cytochrome P-450 and other cellular proteins is a major
part in the response.  These proteins are involved in the ultimate
metabolism of the xenobiotic agent but paradoxically, often activate its
toxic and carcinogenic potential.

The goal of this proposal is to define the regulation of a set of genes
which are induced by aryl hydrocarbons in mice.  We plan to apply
previously used recombinant DNA technologies to identify the level of
regulation of several cytochrome P-450 proteins and to extend the analysis
to include other hydrocarbon inducible genes.  The precise localization and
characterization of the regulatory elements associated with these inducible
genes will then be possible using gene transfer of the identified genes
into appropriate cell types.  By comparing a set of similarly regulated
genes, the mechanisms of hydrocarbon gene regulation may be determined.

## Key facts

- **NIH application ID:** 3178672
- **Project number:** 5R01CA039553-03
- **Recipient organization:** ALBERT EINSTEIN COLLEGE OF MEDICINE
- **Principal Investigator:** Kenneth S Krauter
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $194,005
- **Award type:** 5
- **Project period:** 1985-04-01 → 1988-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3178672

## Citation

> US National Institutes of Health, RePORTER application 3178672, INDUCTION OF GENE EXPRESSION BY CHEMICAL CARCINOGENS (5R01CA039553-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3178672. Licensed CC0.

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