# CLASS II HLA ANTIGENS IN MELANOMA

> **NIH NIH R01** · NEW YORK MEDICAL COLLEGE · 1988 · $133,022

## Abstract

Class II HLA antigens comprise the gene products of the HLA-DR, DQ and DP
loci.  These antigens have a restricted tissue distribution and mediate
cell-cell interactions required to generate immune responses.  Studies with
a limited number of patients have shown that the level of expression of
Class II HLA antigens in metastases from patients with melanoma is
associated with the clinical course of the disease.  After having confirmed
this association on a large number of patients and with long periods of
follow-up, this study will analyze immunological events as mechanisms
underlying the role of Class II HLA antigens in the clinical course of
melanoma.  Specifically utilizing serological and immunochemical assays we
will characterize primary and metastatic lesions for their expression of
HLA-DR, DQ and DP antigens and we will analyze their effect on the degree
of inflammatory response and on the phenotype of infiltrating cells.
Furthermore we will characterize the role of HLA-DR, DQ and DP antigens i)
in the proliferation of T cells stimulated with autologous melanoma cells
isolated fromprimary and metastatic lesions and ii) in the immunogenicity
of melanoma associated antigens recognized by monoclonal antibodies.  The
results of these studies in conjunction with information about the clinical
course of the disease will assess the role of Class II HLA antigens in the
biology of melanoma cells and the clinical significance of the detection of
Class II HLA antigens on melanoma cells.

## Key facts

- **NIH application ID:** 3178693
- **Project number:** 5R01CA039559-03
- **Recipient organization:** NEW YORK MEDICAL COLLEGE
- **SAM.gov UEI:** WK63UJ11C2H7
- **Principal Investigator:** SOLDANO FERRONE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $133,022
- **Award type:** 5
- **Project period:** 1986-06-01 → 1992-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3178693

## Citation

> US National Institutes of Health, RePORTER application 3178693, CLASS II HLA ANTIGENS IN MELANOMA (5R01CA039559-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3178693. Licensed CC0.

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