# BLOOD FLOW IN HUMAN TUMORS DURING LOCAL HYPERTHERMIA

> **NIH NIH R01** · THOMAS JEFFERSON UNIVERSITY · 1987 · $103,760

## Abstract

The overall objective is to characterize human tumor and normal tissue
blood flow during local hyperthermia induced by 915 MHz microwaves.  Tumor
blood flow should be the most important parameter in determining the
effectiveness of hyperthermia because it is the primary mode of heat
transport, often limiting the temperature achieved to less than 42.5
degrees C, as well as the primary mode for the transport of drugs, oxygen,
and nutrients to the tumor.  While tumor blood flow has been studied in
heated animal tumors, the techniques employed are generally unsuitable for
human experimentation.  As a consequence, little data exists on blood flow
in heated human tumors.  This proposal addresses the determination of blood
flow in heated human tissue by measurement of the rate of thermal clearance
when the microwave power is turned off, and the determination of blood flow
before or after heating by use of a thermal dilution probe.  Data will be
generated to investigate the spatial distribution of tumor blood flow,
changes in blood flow during heating, the magnitude of tumor blood flow as
a function of tumor type, volume, and temperature, and changes that occur
in tumor blood flow throughout the treatment regimen.  A possible reduction
in tumor blood flow after the cessation of heating will be investigated and
the ratio of tumor to normal tissue blood flow will be determined.

## Key facts

- **NIH application ID:** 3178758
- **Project number:** 5R01CA039600-03
- **Recipient organization:** THOMAS JEFFERSON UNIVERSITY
- **SAM.gov UEI:** R8JEVL4ULGB7
- **Principal Investigator:** FRANK M WATERMAN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $103,760
- **Award type:** 5
- **Project period:** 1985-09-30 → 1989-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3178758

## Citation

> US National Institutes of Health, RePORTER application 3178758, BLOOD FLOW IN HUMAN TUMORS DURING LOCAL HYPERTHERMIA (5R01CA039600-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3178758. Licensed CC0.

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