# FUNCTIONAL ANALYSIS OF THE ADENO-ASSOCIATED VIRUS GENOME

> **NIH NIH R01** · PRINCETON UNIVERSITY · 1988 · $171,438

## Abstract

Adeno-associated virus (AAV) is a parvovirus which requires
helper function for efficient growth from either one of two tumor
viruses, adenovirus or herpes simplex virus, or vaccinia virus.
AAV not only utilizes gene products from adenovirus, but it
interferes with its growth and with oncogenicity of cells
transformed by adenovirus.  Finally, AAV is able to maintain a
latent infection in the absence of a helper virus by integrating
into host cell DNA.  Thus, AAV is of considerable interest both in
terms of its ability to maintain itself in host cells and its
interaction with its helper viruses.  The long term goal of this
proposal is to describe these interactions in molecular terms.  The
proposal's immediate, specific aims include:  (1) Identification of
the sequence targets for transactivation of the AAV P5
transcriptional control region and dissection of the mechanism of
transactivation; (2) Analysis of the "D" domain within the AAV
terminal repeats with emphasis on their role in packaging; (3)
Isolation and characterization of AAV temperature-sensitive,
linker-insert mutations; and (4) Characterization and elucidation
of the mechanism for AAV-induced interference with adenovirus
E1A mRNA splicing.

## Key facts

- **NIH application ID:** 3178782
- **Project number:** 2R01CA039606-04
- **Recipient organization:** PRINCETON UNIVERSITY
- **SAM.gov UEI:** NJ1YPQXQG7U5
- **Principal Investigator:** THOMAS E SHENK
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $171,438
- **Award type:** 2
- **Project period:** 1985-04-01 → 1989-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3178782

## Citation

> US National Institutes of Health, RePORTER application 3178782, FUNCTIONAL ANALYSIS OF THE ADENO-ASSOCIATED VIRUS GENOME (2R01CA039606-04). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3178782. Licensed CC0.

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