# ANALYSIS OF THE METASTIC POTENTIAL OF TUMORS

> **NIH NIH R01** · UNIV OF NORTH CAROLINA CHAPEL HILL · 1992 · $176,398

## Abstract

Currently there are no diagnostic methods which can be utilized to
index the metastatic potential of primary cancerous lesions.  We
believe that nuclear magnetic resonance (NMR) in conjunction with
other biochemical methods can be developed to predict the
metastatic potential of primary localized tumors.  The primary goal
of this application is to determine which NMR techniques will be
useful in indexing the metastatic potential of various prostate
adenocarcinomas and to correlate these changes with cellular
processes or structures believed to be involved in metastasis.

This study will utilize various prostatic adenocarcinoma tissue
culture cells which have different metastatic ability, implanted
tumors of these various prostatic adenocarcinomas, and human tumors
to answer the following questions:

(i) Whether changes in T1 (spin-lattice) relaxation times, T"
   (spin-spin) relaxation times and diffusion coefficients of
   water protons (D) correlate with the metastatic potential of
   these tumors.

(ii)  If changes in relaxation times and diffusion of water in
these tissues are observed, can they be attributed to changes in
cellular components involved in the metastatic process?

(iii)  Can proton NMR spectroscopy be utilized to determine
differences in the metastatic potential of tumors?

## Key facts

- **NIH application ID:** 3178877
- **Project number:** 5R01CA039633-08
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **SAM.gov UEI:** D3LHU66KBLD5
- **Principal Investigator:** LESTER KWOCK
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $176,398
- **Award type:** 5
- **Project period:** 1985-06-01 → 1994-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3178877

## Citation

> US National Institutes of Health, RePORTER application 3178877, ANALYSIS OF THE METASTIC POTENTIAL OF TUMORS (5R01CA039633-08). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3178877. Licensed CC0.

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