# BIOSTATISTICAL PROBLEMS IN CANCER RESEARCH

> **NIH NIH R01** · DANA-FARBER CANCER INST · 1987 · $61,941

## Abstract

The aims of the research program are to develop statistical techniques that
will be useful in the planning and analysis of environmental and early
detection studies.  Specific objectives in the environmental area include
investigation of the efficiency losses resulting from inexact measurements
of exposure data, and methods for analyzing environmental studies where
there is limited information, at the individual level, for all but those
persons that develop the disease in question.  The former project can lead
to more efficient designs of environmental studies by allowing the varying
costs of different degrees of accuracy in obtaining exposure data to be
balanced with the corresponding efficiencies of the statistical methods for
testing for associations.  The second project explores the potential of
relatively low-cost environmental studies that only require detailed
information on disease cases, and utilize more readily available aggregate
data for the rest of the study population.

Specific objectives for early detection studies include the elucidation of
a parallelism in structure with carcinogenicity experiments, improved
estimators of mean sojourn time in preclinical states, and relaxation of
the commonly used assumption that disease-free duration is independent of
duration in the preclinical state.  The long-term aims of this component of
the research plan are to develop an improved understanding of the results
of screening programs for the early detection of disease.

## Key facts

- **NIH application ID:** 3178897
- **Project number:** 5R01CA039640-03
- **Recipient organization:** DANA-FARBER CANCER INST
- **SAM.gov UEI:** DPMGH9MG1X67
- **Principal Investigator:** Stephen W. Lagakos
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $61,941
- **Award type:** 5
- **Project period:** 1985-06-01 → 1988-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3178897

## Citation

> US National Institutes of Health, RePORTER application 3178897, BIOSTATISTICAL PROBLEMS IN CANCER RESEARCH (5R01CA039640-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3178897. Licensed CC0.

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