# RECEPTOR FOR PDGF

> **NIH NIH R01** · CALIFORNIA INSTITUTE OF TECHNOLOGY · 1987 · $107,179

## Abstract

We propose to analyze the molecular biology of the platelet-derived growth
factor (PDGF) receptor.  PDGF is the major growth-promoting agent in human
blood and interacts with PDGF-specific receptors to induce the growth of
connective tissue cells.  The PDGF receptor is especially important in this
process because it appears to orchestrate the initial events in growth
response to PDGF.  Furthermore, recent observations suggesting that a
protein encoded by an oncogene (PDGF/sis) can induce through the PDGF
receptor the expression of another oncogene (c-myc) implies a possible role
for the PDGF receptor in certain types of malignant growth.  We plan to
carry out final purification and protein sequence analysis on the mouse and
human PDGF receptor proteins.  Synthetic oligonucleotides based on reverse
transaction of the amino acid sequence of the PDGF receptor protein,
followed by standard DNA walking techniques, will be used to isolate cDNA
clones encoding the complete PDGF receptor transcript.  The PDGF receptor
cDNA clones will be used to isolate and characterize the PDGF receptor gene
from cosmid libraries.  We plan to sequence the coding and presumed
regulatory regions of the PDGF receptor gene.  In addition, we plan to
examine the role of PDGF and of the PDGR receptor in transformation.  We
will use DNA-mediated gene transfer to determine if the PDGF receptor gene
is capable of acting as a transforming and/or sufficient to make
nonresponsive cells responsive to PDGF.  We plan to examine a large and
diverse panel of nontransformed and transformed derivative cell lines for
PDGF and PDGF receptor.  (J)

## Key facts

- **NIH application ID:** 3178954
- **Project number:** 5R01CA039666-03
- **Recipient organization:** CALIFORNIA INSTITUTE OF TECHNOLOGY
- **SAM.gov UEI:** U2JMKHNS5TG4
- **Principal Investigator:** LEROY E HOOD
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $107,179
- **Award type:** 5
- **Project period:** 1985-09-01 → 1988-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3178954

## Citation

> US National Institutes of Health, RePORTER application 3178954, RECEPTOR FOR PDGF (5R01CA039666-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3178954. Licensed CC0.

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