# RADIOLABELED ANTIBODY THERAPY OF LYMPHOMA

> **NIH NIH R01** · FRED HUTCHINSON CANCER RESEARCH CENTER · 1987 · $76,040

## Abstract

The purpose of the proposed study is to continue our evaluation of the
therapy of malignant disease with radiolabeled antibodies.  We will use
I131-labeled anti-Thy 1.1 monoclonal antibodies to treat established AKR/J
Thy 1.1+ lymphomas growing in AKR/Cu (Thy 1.2+) mice, where the target
antigen is tumor specific, and in AKR/J (Thy 1.1+) mice, where the target
antigen is expressed on normal T-cells in addition to tumor.  Preliminary
studies have shown that such treatment is effective against subcutaneous
tumor in a setting where antibody is tumor specific.  We now propose to
examine the factors influencing the delivery of radiation to a solid tumor
including the immunologic and pharmacologic characteristics of the carrier
antibody molecule, as well as the distribution of the target antigen on
both normal and malignant cells.  The efficacy and toxicity of
I131-antibody regimens delivering radiation to tumor at varying dose rates
will be studied.  The results of these studies should help elucidate
principals governing therapy with radiolabeled antibodies and facilitate
design of future clinical trials in humans.

## Key facts

- **NIH application ID:** 3178971
- **Project number:** 5R01CA039675-03
- **Recipient organization:** FRED HUTCHINSON CANCER RESEARCH CENTER
- **SAM.gov UEI:** HMSNCM57QNR5
- **Principal Investigator:** CHRISTOPHER C BADGER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $76,040
- **Award type:** 5
- **Project period:** 1985-09-01 → 1988-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3178971

## Citation

> US National Institutes of Health, RePORTER application 3178971, RADIOLABELED ANTIBODY THERAPY OF LYMPHOMA (5R01CA039675-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3178971. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*