# PREDICTION OF RADIATION/PHOTOTHERAPY RESPONSE WITH NMR

> **NIH NIH R01** · HENRY FORD HOSPITAL · 1988 · $149,255

## Abstract

Presently, there is no early marker for the effectiveness of radiation
therapy and phototherapy in the treatment of cancer.  The goal of the
present proposal is to document cellular and metabolic changes that occur
in tumors in response to two therapeutic modalities, radiation therapy and
phototherapy, administered at subcurative and curative treatment levels.
In vivo 31P Nuclear Magnetic Resonance (NMR) will be employed to monitor
intracellular pH and relative concentrations of high energy phosphate
metabolites in conjunction with PO2 and pH microelectrode measurements.
All measurements will be correlated with biological endpoints.  Studies
will be performed on C3H mouse mammary carcinoma.  Experimental
determinations made both during and following therapy will define both
acute and long term response to the treatment.  Our long term objective is
to establish in vivo 31P NMR spectroscopy as a method for non-invasively
assessing tumor response to radiation therapy and phototherapy.

## Key facts

- **NIH application ID:** 3179031
- **Project number:** 5R01CA039697-03
- **Recipient organization:** HENRY FORD HOSPITAL
- **Principal Investigator:** MICHAEL CHOPP
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $149,255
- **Award type:** 5
- **Project period:** 1986-04-01 → 1991-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3179031

## Citation

> US National Institutes of Health, RePORTER application 3179031, PREDICTION OF RADIATION/PHOTOTHERAPY RESPONSE WITH NMR (5R01CA039697-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3179031. Licensed CC0.

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