# SYNTHESIS OF FREDERICAMYCIN

> **NIH NIH R01** · BROWN UNIVERSITY · 1987 · $111,813

## Abstract

An efficient and convergent chemical synthesis of Fredericamycin A, an
antitumor antibiotic isolated in low yield from the broth of Streptomyces
griseus (FCRC-48), is the goal of this project.  Fredericamycin is very
active in the KB, P388, and L1210 cell lines and it inhibits the growth of
ovarian tumor in a human tumor cloning system.

Fredericamycin would be a candidate for clinical trials if the current
problem of erratic test results could be solved.

The irreproducible test results are currently attributed to solubility
problems.  Therefore, an especially important part of our program will be
the testing of synthetic intermediates and also functionalized
fredericamycins in an effort to find analogs with better solubility as well
as better or comparable activity.

A long term goal of this project is the modification of our scheme to the
synthesis of chiral material.  This will allow assignment of absolute
configuration to the antibiotic as well as provide material identical in
all respects to the natural product.

## Key facts

- **NIH application ID:** 3179085
- **Project number:** 5R01CA039717-03
- **Recipient organization:** BROWN UNIVERSITY
- **SAM.gov UEI:** E3FDXZ6TBHW3
- **Principal Investigator:** Kathlyn A Parker
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $111,813
- **Award type:** 5
- **Project period:** 1985-04-01 → 1988-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3179085

## Citation

> US National Institutes of Health, RePORTER application 3179085, SYNTHESIS OF FREDERICAMYCIN (5R01CA039717-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3179085. Licensed CC0.

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