# INTRAPERITONEAL IMMUNOTOXINS

> **NIH NIH R01** · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 1990 · $121,270

## Abstract

The objective of this study is the development and evaluation of
anti-tumor immunotoxins (IT's) for intraperitoneal therapy of
advanced intraperitoneal malignancy.  Immunotoxins (monoclonal
antibody-ricin A chain conjugates) directed against carcinoembronic
antigen and human transferrin receptor will be used.  The anti-
tumor effects of these IT's will be evaluated in human tumor
xenografts established as intraperitoneal tumors in nude mice.
Alternate methods of immunotoxin construction will be evaluation,
to optimize anti-tumor efficacy in these models.  Further
enhancement of anti-tumor effect of the IT's will be sought, by the
in vivo use of modified forms of the IT potentiator monensin
(monensin linoleate, monensin in emulsion, and liposomal monensin.)
Augmentation of IT anti-tumor effect by combination with
radioimmunotherapy (90 Yttrium antibody or 90 Yttrium-IT) will also
be examined.  A limited clinical trial of i.p. IT's in refractory
intraperitoneal malignancy will be performed.  This trial will
investigate toxicity and efficacy of i.p. IT's, and the
biodistribution of 111 Indium-IT's after i.p. infusion will be
determined by external scanning and tissue biopsy.  These studies
should yield important information regarding development of IT's
as clinical anti-cancer agents.

## Key facts

- **NIH application ID:** 3179147
- **Project number:** 5R01CA039748-05
- **Recipient organization:** UNIV OF MASSACHUSETTS MED SCH WORCESTER
- **SAM.gov UEI:** MQE2JHHJW9Q8
- **Principal Investigator:** THOMAS W. GRIFFIN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $121,270
- **Award type:** 5
- **Project period:** 1985-09-30 → 1990-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3179147

## Citation

> US National Institutes of Health, RePORTER application 3179147, INTRAPERITONEAL IMMUNOTOXINS (5R01CA039748-05). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3179147. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*