# SIGNAL TRANSDUCTION BY CELLULAR PROTOONCOGENES

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 1988 · $238,851

## Abstract

We wish to continue our studies into the mechanism of action of
cellular and viral oncogenes in proliferation and differentiation.
By combining molecular biological techniques with cell biological
ones, we have been able to establish unique assays for the analysis
of the function of the cellular ras protooncogene and oncogene
proteins in proliferation and differentiation, and for the analysis
of the biological and biochemical activity of the src protooncogene
and oncogene proteins.  We will continue to evaluate the biological
and biochemical changes that occur in living cells microinjected
with the purified ras proteins or with neutralizing antibodies
directed against these proteins.  We will examine the biochemical
role of the ras proteins in the regulation of phospholipid turnover
and intracellular pH, as suggested by our microinjection studies.
Likewise, we will continue our newly begun studies of the function
of the src proteins in proliferation and differentiation.  For
these we have utilized monoclonal antibodies to c- and v-src and
have begun to use baculovirus expression vectors for the production
of the src proteins in insect cells.  Through this work, we hope
to continue contributing to the understanding of the mechanism of
cellular transformation by oncogenes, and in parallel to the
understanding of the normal biological roles of the cellular
protooncogene proteins in proliferation and differentiation.

## Key facts

- **NIH application ID:** 3179203
- **Project number:** 2R01CA039811-04
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **SAM.gov UEI:** UYTTZT6G9DT1
- **Principal Investigator:** JAMES R FERAMISCO
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $238,851
- **Award type:** 2
- **Project period:** 1988-04-05 → 1993-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3179203

## Citation

> US National Institutes of Health, RePORTER application 3179203, SIGNAL TRANSDUCTION BY CELLULAR PROTOONCOGENES (2R01CA039811-04). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3179203. Licensed CC0.

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