# NONPARAMETRIC STATISTICAL TESTS FOR CENSORED DATA

> **NIH NIH R01** · DANA-FARBER CANCER INST · 1990 · $167,287

## Abstract

This project will continue the work on statistical methods used
with censored survival data that was funded in the last grant
period.  The questions studied fall into three main areas:
censored data regression methods; significance testing procedures
for two or more samples of censored data; and a unified
treatment of the martingale approach to the analysis of counting
processes and censored data.

In censored data regression, we will study:  (a) diagnostics for
proportional hazards regression methods based on generalized
residuals for these models and on an improved kernel estimation
method for hazard functions; (b) models for survival data with
time dependent hazard ratios, especially models in which
covariate effects diminish over time; (c) flexible data analytic
proportional hazards models in which non-linear covariate effects
are estimated with splines; and (d) methods for adjusting for
covariate measurement errors with censored data.

Significance testing procedures will include:  (a) extensions of the
work of O'Sullivan and Fleming (1986) on non-rank, asymptotically
nonparametric methods for censored failure time data; (b)
methods for evaluating the therapeutic index of new
pharmaceutical agents being studied by Federal regulatory
agencies; (c) extensions of paired data methods for censored data;
and (d) methods for estimating treatment effects in trials using
group sequential designs.

Work on the now partially completed research monograph will be
extended to include simplified proofs of asymptotic results for
censored data testing and regression methods and a unified
treatment of the proportional hazards regression model.

## Key facts

- **NIH application ID:** 3179301
- **Project number:** 5R01CA039929-06
- **Recipient organization:** DANA-FARBER CANCER INST
- **SAM.gov UEI:** DPMGH9MG1X67
- **Principal Investigator:** DAVID P HARRINGTON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $167,287
- **Award type:** 5
- **Project period:** 1984-09-01 → 1990-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3179301

## Citation

> US National Institutes of Health, RePORTER application 3179301, NONPARAMETRIC STATISTICAL TESTS FOR CENSORED DATA (5R01CA039929-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3179301. Licensed CC0.

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