# BIOMATHEMATICAL APPROACHES TO CANCER

> **NIH NIH R01** · FRED HUTCHINSON CANCER RESEARCH CENTER · 1987 · $374,505

## Abstract

This is a multi-investigator project that applies mathematical and statistical
methods to the study of clinical and experimental cancer and of biological
mechanisms relevant to cancer.  (1) Data on human cancer incidence are being
compared to a mathematical model that incorporates cell kinetics as well as
transition rates for each two stages.  The role of smoking in the origin of
various human cancers is also being studied.  (2) Statistical methods are being
developed and utilized in the analysis of individuals infected with hepatitis B
virus, their rates of conversion to the carrier state, and their acquisition of
primary hepatocellular cancer.  Mathematical models are also being applied to
the study of cancer in rats as a function of early diet and growth.  (3)
Stochastic methods are being employed to analyze such diverse problems as the
incidence of cancer in families and local communities, the estimation of numbers
of cell surfaces, and the structures of proteins and nucleic acids.  (4)
Mathematical analysis is being performed on the mitotic cycle of cells,
utilizing data obtained by time-lapse microcinematography and by two-parameter
flow cytometry.

## Key facts

- **NIH application ID:** 3179360
- **Project number:** 5R01CA039949-04
- **Recipient organization:** FRED HUTCHINSON CANCER RESEARCH CENTER
- **SAM.gov UEI:** HMSNCM57QNR5
- **Principal Investigator:** SURESH H MOOLGAVKAR
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $374,505
- **Award type:** 5
- **Project period:** 1984-08-01 → 1988-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3179360

## Citation

> US National Institutes of Health, RePORTER application 3179360, BIOMATHEMATICAL APPROACHES TO CANCER (5R01CA039949-04). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3179360. Licensed CC0.

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