# SYNTHESIS OF PHYSIOLOGICALLY ACTIVE NATURAL PRODUCTS

> **NIH NIH R01** · YALE UNIVERSITY · 1988 · $163,408

## Abstract

This proposal seeks to continue current studies in the synthesis of
cytotoxic and antineoplastic natural products.  New chemical methods are to
be developed along with the preparation of substrates for biological
evaluation.  The completion of the synthesis of eriolanin and eriolangin is
planned.  Methods developed for the synthesis of aromatin will be applied
to fastigilin-type pseudoguaianolides.  Experience gained with the
Cope-Claisen rearrangement will be utilized in the synthesis of the
cytotoxic substance, quadrone.  Finally, studies will be started which will
be applicable to the synthesis of the antitumor substance, bruceantin.

## Key facts

- **NIH application ID:** 3179390
- **Project number:** 5R01CA039976-15
- **Recipient organization:** YALE UNIVERSITY
- **SAM.gov UEI:** FL6GV84CKN57
- **Principal Investigator:** FREDERICK E ZIEGLER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $163,408
- **Award type:** 5
- **Project period:** 1985-09-01 → 1990-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3179390

## Citation

> US National Institutes of Health, RePORTER application 3179390, SYNTHESIS OF PHYSIOLOGICALLY ACTIVE NATURAL PRODUCTS (5R01CA039976-15). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3179390. Licensed CC0.

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