# SYNTHESIS OF PHYSIOLOGICALLY ACTIVE NATURAL PRODUCTS

> **NIH NIH R01** · YALE UNIVERSITY · 1993 · $177,097

## Abstract

This program proposes to conduct studies on methods and strategies
applicable to the synthesis of a number of natural products that display
a range of physiological activity.  In so doing, new methods of chemical
synthesis and the mechanism by which these reactions occur will be
explored.  The success of such a program can lead to new methods of
chemical synthesis and to new entries into drug design.

Mitomycin C is currently used in Japan in the treatment of certain
cancers.  The recently isolated mitomycin congeners FR900482 and FR
66979, and the synthetic derivative FR973, have been shown in some
instances to have superior activity compared to mitomycin C.  New
synthetic approaches to the formation and functionalization of the
skeleton of these compounds, and hopefully the compounds themselves,
will be explored.

One group of compounds to be studied is the trichothecenes, mold
metabolites derived from Fusarium species.  Members of this class of
compounds include anguidine (antitumor and mycotoxic agent), which is an
intermediate in the preparation of T-2 toxin (mycotoxin and causative
agent of alimentary toxic aleukia (ATA)), and FS-2 (embryotoxic agent).

The fourth objective is the rational synthesis of scopadulcic acid B, an
antiviral agent closely related to the structure of the antiviral and
antimitotic agent, aphidicolin.

## Key facts

- **NIH application ID:** 3179392
- **Project number:** 5R01CA039976-18
- **Recipient organization:** YALE UNIVERSITY
- **SAM.gov UEI:** FL6GV84CKN57
- **Principal Investigator:** FREDERICK E ZIEGLER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $177,097
- **Award type:** 5
- **Project period:** 1985-09-01 → 1995-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3179392

## Citation

> US National Institutes of Health, RePORTER application 3179392, SYNTHESIS OF PHYSIOLOGICALLY ACTIVE NATURAL PRODUCTS (5R01CA039976-18). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3179392. Licensed CC0.

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