# ABSORPTION & METABOLISM OF CAROTENOIDS

> **NIH NIH R01** · GEORGE WASHINGTON UNIVERSITY · 1988 · $85,542

## Abstract

Since carotenoids have proven to be anticancer agents elucidation
of the mechanism of their action is our ultimate goal.  In order to
achieve this we have to understand (a) how the carotenoids are
absorbed across the gut, (b) what changes do they undergo and (c)
how are they transported in circulation and distributed in various
parts of the body.  It would also be important to find out how
these processes are affected when carotenoids are consumed in
excess.  We plan to systematically analyze all the above issues
using rats as the experimental animals.  We will use both whole
animal and isolated enzyme systems to solve these questions.  The
knowledge gained in these investigations could lead to our
understanding of carotenoid action in the treatment of cancer in
man.

## Key facts

- **NIH application ID:** 3179416
- **Project number:** 5R01CA039999-02
- **Recipient organization:** GEORGE WASHINGTON UNIVERSITY
- **SAM.gov UEI:** ECR5E2LU5BL6
- **Principal Investigator:** RAJ M LAKSHMAN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $85,542
- **Award type:** 5
- **Project period:** 1987-04-01 → 1990-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3179416

## Citation

> US National Institutes of Health, RePORTER application 3179416, ABSORPTION & METABOLISM OF CAROTENOIDS (5R01CA039999-02). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3179416. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*