# CONTRAST MEDIA REDUCE CSF PRODUCTION MECHANISM/TOXICITY

> **NIH NIH R01** · UNIVERSITY OF ROCHESTER · 1987 · $111,668

## Abstract

The causes of the adverse responses to contrast media (CM) are not well
understood but may involve CM-induced alterations of the central nervous
system (CNS).  The blood brain barrier (BBB) strictly controls access of
substance to the CNS.  The rate of cerebrospinal fluid (CSF) production is
a key factor in eliminating substances from the CNS.  These two factors
thus maintain and control the chemical environment of the CNS.  If either
factor is disrupted, toxic manifestations could occur.  Both factors can be
altered by CM.  Contrast media are up to several hundred times more toxic
in the CNS than systemically, and are able to disrupt the BBB.  Experiments
in dogs from this laboratory show that moderate doses of both ionic and
non-ionic intravenous CM substantially decrease CSF production.  Therefore,
CM might be expected to alter the environment of the CNS and result in
toxicity.  The mechanisms of CM effects on the production of CSF will be
studied in the proposed work.  Conscious and anesthetized laboratory animal
models and in vitro preparations will be employed to determine:  the
mechanisms of CM-induced ecreased CSF production; the extent of CNS
toxicity resulting from this action of CM; changes in the concentration,
retention and kinetics of substances in the CNS caused by CM; enhancement
by certain risk factors of CM-induced toxicity by additionally decreasing
CSF production or by predisposing the BBB to damaging effects of CM; and if
it is possible to protect from these effects of CM pharmacologically.

## Key facts

- **NIH application ID:** 3179662
- **Project number:** 5R01CA040119-03
- **Recipient organization:** UNIVERSITY OF ROCHESTER
- **SAM.gov UEI:** F27KDXZMF9Y8
- **Principal Investigator:** Phillip Harnish
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $111,668
- **Award type:** 5
- **Project period:** 1985-09-30 → 1989-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3179662

## Citation

> US National Institutes of Health, RePORTER application 3179662, CONTRAST MEDIA REDUCE CSF PRODUCTION MECHANISM/TOXICITY (5R01CA040119-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3179662. Licensed CC0.

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