# ORGANOTRANSITION METAL ENTRY TO ANTITUMOR QUINONES

> **NIH NIH R01** · EMORY UNIVERSITY · 1993 · $207,224

## Abstract

The facile introduction of varied substituents about an aromatic or
heteroaromatic core during structure-activity relationship studies is a
recurring problem encountered in the development of medicinal agents that
are based on small organic molecules.  Within this context, new and
general strategies for the regiospecific construction of aromatic,
heteroaromatic, and related molecules of medicinal interest (quinones,
pyrones) are important to the overall mission of the NIH.

In this renewal proposal, a variety of new synthetic methods for the
construction of substituted quinones, aromatics, benzannulated
heteroaromatics, pyrones, cycloheptadienones, and cyclooctadienones are
described.  The majority of the methods center on transition metal and
thermally mediated transformations of cyclobutenones bearing reactive
functionality at the 4-position.  In a number of cases, transition metal
mediated chemistry is used to construct the requisite precursors.

Successful development of the newly suggested synthetic strategies will
introduce powerful new methods for the synthesis of important cyclic
organic molecules such as quinones, aromatic and heteroaromatic
molecules, and pyrones.  It is anticipated that the proposed chemistry
could have a significant impact on the development of medicinal agents
possessing anticancer, antibiotic, antifungal, and possibly antiviral
activities.

## Key facts

- **NIH application ID:** 3179718
- **Project number:** 2R01CA040157-10
- **Recipient organization:** EMORY UNIVERSITY
- **SAM.gov UEI:** S352L5PJLMP8
- **Principal Investigator:** LANNY S LIEBESKIND
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $207,224
- **Award type:** 2
- **Project period:** 1979-07-01 → 1998-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3179718

## Citation

> US National Institutes of Health, RePORTER application 3179718, ORGANOTRANSITION METAL ENTRY TO ANTITUMOR QUINONES (2R01CA040157-10). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3179718. Licensed CC0.

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