# AN ORGANOTRANSITION METAL ENTRY TO ANTITUMOR QUINONES

> **NIH NIH R01** · EMORY UNIVERSITY · 1987 · $166,476

## Abstract

This project concerns a study of the organotransition metal complexes as
precursors to quinone compounds.  Through such a study we hope to gain a better
understanding of how to use organotransition metal species in the synthesis of
complex organic molecules and at the same time develop general methods for
quinone synthesis which will open up simple routes to anticancer quinones.
Specifically, we have focused on the synthesis of maleoyl- and phthaloylmetal
complexes and on their reaction with alkynes to give benzoquinones and
naphthoquinones.  We have been successful in developing simple synthesis of such
complexes and in finding a general reaction with alkynes.

## Key facts

- **NIH application ID:** 3179720
- **Project number:** 5R01CA040157-04
- **Recipient organization:** EMORY UNIVERSITY
- **SAM.gov UEI:** S352L5PJLMP8
- **Principal Investigator:** LANNY S LIEBESKIND
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $166,476
- **Award type:** 5
- **Project period:** 1979-07-01 → 1988-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3179720

## Citation

> US National Institutes of Health, RePORTER application 3179720, AN ORGANOTRANSITION METAL ENTRY TO ANTITUMOR QUINONES (5R01CA040157-04). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3179720. Licensed CC0.

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