# INDUCED TUMOR GROWTH AND DRUG METABOLISM PREDICT RESPONS

> **NIH NIH R01** · JOHNS HOPKINS UNIVERSITY · 1987 · $189,735

## Abstract

Based on the hypothesis of increased sensitivity of residual tumor to
cycle-active drug during the growth-perturbed state following initial
cytoreductive therapy, we have designed studies which have met with
clinical success.  To explore this hypothesis and refine our therapies, we
will identify interdependent cell growth and pharmacological parameters
which may together predict for clinical responsiveness in patients with
acute myelogenous leukemia who receive treatment with a timed sequence of
cell cycle-dependent cytarabine (ara-C).  By examining the residual
homogeneous clonogenic cell uncovered in vivo by initial drug therapy and
in vitro after growth stimulation, we have a unique opportunity to
determine growth-altered ara-C pharmacology in this non-steady state.  To
define and apply criteria that can be used clinically to discriminate ara-C
sensitive and ara-C resistant populations of leukemic cells, we will
measure in vitro and in vivo the effect of drug-primed cell growth on net
intracellular ara-C activation and distribution, drug delivery, and
clinical response to timed sequential therapy with ara-C.  These
cytokinetic and biochemical parameters obtained longitudinally at initial
diagnosis, during remission induction with timed sequential therapy, and at
leukemia relapse will be examined to determine if changing patterns of
induced cell growth and ara-C metabolism in these cells will over time
correlate with achievement and duration of unmaintained complete remission.
The aim is to use those defined clinical-laboratory correlates of response
to designate proper intensive therapies in remission or at relapse.

## Key facts

- **NIH application ID:** 3179810
- **Project number:** 5R01CA040187-03
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **SAM.gov UEI:** FTMTDMBR29C7
- **Principal Investigator:** JUDITH E KARP
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $189,735
- **Award type:** 5
- **Project period:** 1985-07-01 → 1988-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3179810

## Citation

> US National Institutes of Health, RePORTER application 3179810, INDUCED TUMOR GROWTH AND DRUG METABOLISM PREDICT RESPONS (5R01CA040187-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3179810. Licensed CC0.

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