# DESMOPLASTIC RESPONSE TO TUMOR INVASION

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 1990 · $111,555

## Abstract

The desmoplastic response to tumor invasion is a poorly understood
host myofibroblast-mediated collagenous response responsible for
the "hard lump" appearance of many human cancers.  This competitive
renewal will continue to study both the pathogenesis of the
response as well as the effects of the response on tumor invasion
and metastasis.  The first basic aim will be to further
characterize and purify the 25,000 M.W. myofibroblast growth
factor, compare it to known growth factors, demonstrate a role for
this factor in the pathogenesis of the response with in vivo
studies of myofibroblast expression of c-myc, c-fos, elastin, Type
I, and Type V collagen genes and will in vivo studies with the
desmoplasia-inducing c-Has-ras transfected high p21 MCF-7 human
breast carcinoma cell line.  The second basic aim will be to study
the role of the 40,000 M.W. desmoplastic inhibitor of
metalloproteinases (DIMP) in conferring to the desmopastic response
a partial but not total resistance to tumor invasion and
metastasis.  This will involve a detailed comparison of DIMP with
TIMP (tissue inhibitor of metalloproteinases) and an evaluation of
a possible mechanism which would allow successful tumor
collagenolysis even whether the desmoplastic response, being only
partially successful in inhibiting invasion, ultimately exerts
selection pressure for subpopulations of the primary tumor with
increased metastatic potential.

## Key facts

- **NIH application ID:** 3179900
- **Project number:** 5R01CA040225-06
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **SAM.gov UEI:** RN64EPNH8JC6
- **Principal Investigator:** Sanford Howard Barsky
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $111,555
- **Award type:** 5
- **Project period:** 1985-07-01 → 1993-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3179900

## Citation

> US National Institutes of Health, RePORTER application 3179900, DESMOPLASTIC RESPONSE TO TUMOR INVASION (5R01CA040225-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3179900. Licensed CC0.

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