# STRATEGIES FOR THE SYNTHESIS OF ANTI-TUMOR COMPOUNDS

> **NIH NIH R01** · UNIVERSITY OF CHICAGO · 1987 · $97,719

## Abstract

This proposal is directed towards the development of new approaches to the
construction of naturaly occurring substances with important biological
activity.  The goal of the studies that we propose herein is not the total
synthesis of complex organic molecules per se, but rather the development
of new strategies in synthetic chemistry which will have applications
beyond the construction of any particular class of natural products.

Three distinct areas of research are outlined in this proposal: (1) the use
of asymmetric radical cyclizations to control the absolute stereochemistry
of carbon-carbon bond formation, (2) a variant of the de Mayo reaction
which leads to the formation of medium rings and structurally complex
organic molecules, and (3) the development of transannular radical
cyclizations for the construction of complex organic molecules.

The strategy that we have outlined for the synthesis of biologically active
natural products using transannular radical cyclizations has counterparts
in the Diels-Alder reaction, cationic polyene cyclization, and arene-olefin
cycloaddition.  More than one carbon-carbon bond and considerable
stereochemical information is generated in a single synthetic operation.
The constructions of the carbon skeleta of the anti-tumor compounds
coriolin and taxol outlined in this proposal attest to the considerable
potential of this methodology in the synthesis of medicinally important
substances.

## Key facts

- **NIH application ID:** 3179955
- **Project number:** 5R01CA040250-03
- **Recipient organization:** UNIVERSITY OF CHICAGO
- **SAM.gov UEI:** ZUE9HKT2CLC9
- **Principal Investigator:** JEFFREY D WINKLER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $97,719
- **Award type:** 5
- **Project period:** 1985-07-01 → 1988-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3179955

## Citation

> US National Institutes of Health, RePORTER application 3179955, STRATEGIES FOR THE SYNTHESIS OF ANTI-TUMOR COMPOUNDS (5R01CA040250-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3179955. Licensed CC0.

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