# REGULATION OF HEMATOPOIESIS BY NK CELLS

> **NIH NIH R01** · WISTAR INSTITUTE · 1987 · $176,284

## Abstract

The overall objective of this project is to study the role of human natural
killer (NK) cells in the regulation of hematopoiesis in physiological and
pathological conditions.  The underlying hypothesis of this proposal is
that NK cells are engaged in the regulation of reactions against self to
ensure homeostasis.  Rejection of bone marrow graft and some pathological
states of bone marrow failure, in which the role of NK cells was
demonstrated, would be a consequence of an enhancement or pathological
alteration of this physiological regulatory mechanism.  The
NK-cell-mediated natural resistance to leukemia-lymphomas is probably
another manifestation, in pathological conditions, of the hemostatic
function of NK cells.

Human NK cells inhibit proliferation-differentiation of human bone marrow
hematopoietic precursor cells in vitro.  This effect is mediated, in part
or completely, by release of a soluble colony-inhibiting activity (NK-CIA),
probably identical to the NK-derived cytotoxic factor (NKCF) released by
NKC cells upon interaction with target cells.  The mechanism by which NK
cells and NK-CIA suppress hematopoiesis will be characterized.  The long
range objective is to apply the knowledge acquired from these studies to
analyze the possible role of NK cells in patients with transient or severe
bone marrow failure and in patients with leukemia-lymphomas.  (SR)

## Key facts

- **NIH application ID:** 3179978
- **Project number:** 5R01CA040256-03
- **Recipient organization:** WISTAR INSTITUTE
- **SAM.gov UEI:** DW1XZMGNFBL4
- **Principal Investigator:** DANIELA SANTOLI
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $176,284
- **Award type:** 5
- **Project period:** 1985-09-01 → 1988-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3179978

## Citation

> US National Institutes of Health, RePORTER application 3179978, REGULATION OF HEMATOPOIESIS BY NK CELLS (5R01CA040256-03). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3179978. Licensed CC0.

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