# REGULATION OF HEMATOPOIESIS BY NK CELLS

> **NIH NIH R01** · WISTAR INSTITUTE · 1991 · $191,171

## Abstract

Natural Killer (NK) cells have been proposed to play an important
regulatory role in hematopoiesis and in adaptive immune responses,
either through direct cellular interactions or by releasing
lymphokines and other soluble factors.  The overall objective of
this project is to study the role of human NK cells in the
regulation of hematopoiesis in physiological and pathological
conditions.  The underlying hypothesis of this proposal is that NK
cells are engaged in the regulation of reactions against self to
ensure homeostasis.  Rejection of bone marrow graft and some
pathological states of bone marrow failure, in which the role for
NK cells was demonstrated, would be a consequence of an enhancement
or pathological alterations of this physiological regulatory
mechanism.  The NK cell-mediated natural resistance to leukemia-
lymphomas is probably another manifestation, in pathological
conditions, of the homeostatic function of NK cells.

In order to characterize the mechanisms of NK cell-mediated
regulation of normal and pathological hematopoiesis we will:

-  analyze the ability of NK cells to produce lymphokines
affecting hematopoiesis, both stimulatory and inhibitory, and study
the regulation of their production by NK cells;

-  investigate the cellular interactions between NK cells and bone
marrow cells, leading to inhibition of colony formation and to
lymphokine production;

-   study the effect of NK cells and NK cell-derived factors on
leukemic precursor cells;

-   dissect at tissue level or using multicellular culture systems
the cellular and humoral interactions involving NK cells in the
bone marrow from normal individuals or from patients with
hematological disorders.

## Key facts

- **NIH application ID:** 3179980
- **Project number:** 5R01CA040256-06
- **Recipient organization:** WISTAR INSTITUTE
- **SAM.gov UEI:** DW1XZMGNFBL4
- **Principal Investigator:** DANIELA SANTOLI
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $191,171
- **Award type:** 5
- **Project period:** 1985-09-01 → 1993-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3179980

## Citation

> US National Institutes of Health, RePORTER application 3179980, REGULATION OF HEMATOPOIESIS BY NK CELLS (5R01CA040256-06). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3179980. Licensed CC0.

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