# Core B - Clinical Core

> **NIH NIH P30** · UNIVERSITY OF PENNSYLVANIA · 2020 · $877,116

## Abstract

Core B: Clinical Core
Core Leader: David A. Wolk, M.D.; Co-Core Leader: Jason Karlawish, M.D.
Project Summary/Abstract
 The mission of the Penn ADCC Clinical Core is to provide patient data (cognitive, neuroimaging, biofluid,
genetic, autopsy) to support the thematic goals of the ADCC and the broader AD research community. A major
challenge to developing effective therapeutic interventions for disease modification or symptomatic treatment is
the growing understanding that AD is a heterogeneous condition. At least two features characterize this
heterogeneity: mixed and multiple pathologies and differential involvement of brain regions or networks. The
Penn ADCC views this heterogeneity, as well as the potential shared mechanisms of different proteinopathies
and the realization that the antecedents of AD and related disorders occur in preclinical and prodromal stages,
as opportunities to enhance precision in prognostication, disease monitoring, and targeting of underlying
pathophysiology. As such, the major themes of our ADCC in this renewal are to increase the understanding of
(1) the interplay of AD and related disorders pathology in the clinical spectrum of AD, (2) the factors which
result in clinical and network level heterogeneity in AD, and (3) the relationship of these phenomena to models
of transmissibility. The result will be to increase insight into different AD phenotypes and disease mechanisms
through the spectrum of preclinical AD through symptomatic stages. These goals are related to and dependent
on our strong tradition of biomarker studies which continue to be a focus for both Core B and the overall
ADCC, including development and refinement of these measures and investigation into approaches for their
implementation and disclosure in clinical settings.
 The Clinical Core is highly integrated with the other Penn ADCC Cores and it will work towards achieving
the following aims to advance the scientific mission of the Center: (1) To identify and longitudinally evaluate
individuals across the continuum of AD and “normal” cognitive aging, gathering clinical, neuroimaging, and
biosample data with an emphasis on heterogeneity in clinical expression, further enhanced by inclusion of the
FTLD Module. (2) To collaborate with the Outreach and Recruitment Core to facilitate participation of
individuals, with an emphasis on African Americans, in Clinical Core research activities, which will add diversity
critical to understanding the influence of comorbid risk factors and genetics on disease expression. (3) To
foster integration of Core B activities with the other ADCC Cores, including with the Research Education
Component (Core F) to train the next generation of investigators in AD research and with the Data
Management, Biostatistics & Bioinformatics Core (Core C) and the Neuropathology, Genetics & Biomarker
Core (Core D) to collect and manage clinical data, biomarker studies, and biological samples in a manner that
facilitates local, national...

## Key facts

- **NIH application ID:** 9962203
- **Project number:** 5P30AG010124-30
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** DAVID A WOLK
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $877,116
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9962203

## Citation

> US National Institutes of Health, RePORTER application 9962203, Core B - Clinical Core (5P30AG010124-30). Retrieved via MORVS 2026-10-28 from https://api.morvs.ai/grant/nih/9962203. Licensed CC0.

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