Neural communication relies on both chemical and electrical signals, with neurotransmitters acting across multiple timescales to regulate brain function. To fully understand this complexity, we need implantable devices capable of simultaneously monitoring multiple types of brain signals over extended periods. Although significant progress has been made, current technologies still lack reliable, long-term, multimodal detection capabilities. This CAREER project aims to develop a transformative neural interface designed to monitor multiple brain signals with high spatial resolution and across various timescales. By integrating advanced materials with innovative fabrication techniques, the device will enhance signal detection accuracy while minimizing the brain’s immune response, ensuring stable, long-term functionality. In addition to advancing fundamental scientific knowledge, this research has the potential to improve human health by enabling the development of better treatments for neurological and psychiatric disorders. The project supports national priorities by promoting scientific progress and enhancing public health through next-generation neurotechnologies. It also includes a strong educational component, offering hands-on training and research opportunities for undergraduate and graduate students. Outreach efforts will engage K-12 students and the broader community through interactive demonstrations and discussions on neurotechnologies, their applications, and ethical