This award is funded by the Major Research Instrumentation and Chemistry Research Instrumentation Programs. The University of New Hampshire is acquiring an isothermal titration calorimeter with a cleaning accessory to support the research of Professor Sean Edington along with colleagues Aylin Aykanat, Eva Balog, Linqing Li, Nate Oldenhuis, Roy Planalp, and Patricia Stone. This instrument facilitates research in the areas of chemistry, protein design, materials science, biosensing, biometal metabolism, biological signaling, and molecular biology. The instrument makes accurate and precise measurements of how strongly different molecules bind to one another and is configured for automatic operation, allowing large numbers of samples to be measured. Accurate measurements of binding interactions are essential to chemists and biologists carrying out frontier research. There is only one other automated publicly accessible device of this type in New England. This instrument therefore increases local, state, and regional scientific capacity, enabling new research projects at multiple universities. This instrument enhances the educational, research, and research training of students at the University of New Hampshire. Through integration in instrument training sessions, coursework, and instrument center outreach events, the instrument enhances the education of students and community members at the University of New Hampshire and beyond. Research enabled by this instrument is focused