The broader impact/commercial potential of this small business innovation research (SBIR) Phase I project lies in its potential to transform outcomes for US burn injury survivors; a population burdened by disfigurement, physical limitation, and long-term psychological impacts. While current treatments focus primarily on survival, many patients face permanent reductions in quality of life due to scarring and contractures. This project aims to develop a novel burn care system that actively manages serious burn wounds to reduce scarring and provide better patient outcomes. If successful, the technology could reduce long-term complications, support social reintegration, enable return to work, and enhance quality of life. The economic burden on US health systems is also significant: the average cost of care for a serious burn injury requiring hospitalization exceeds $250,000 and may extend for months or even years. Globally, medical systems pay over $2.6 billion annually on the care and rehabilitation of individuals with serious burns. This project addresses a critical unmet need by aiming to improve patient healing outcomes, and as a consequence will also reduce the need for secondary surgical revision and therapy, thereby decreasing the cost burden on health systems across the country. This Small Business Innovation Research (SBIR) Phase I Project seeks to validate a technology that integrates a three-part sequence of topical anti-scarring therapeutics with a purpose-built dr