The broader/commercial impact of this Small Business Innovation Research (SBIR) Phase II project is to advance a new crop protection technology that strengthens U.S. leadership in agricultural biotechnology, supports global food security, and improves the resilience of American farmers. The project focuses on a biopesticide that targets Sudden Death Syndrome, a major fungal disease responsible for up to $500 million in annual losses for U.S. soybean growers. Unlike traditional synthetic pesticides, this microbe-based product offers a safer solution that reduces the need for chemical inputs while maintaining high yields. By improving crop health and minimizing losses, the innovation can help farmers use land more efficiently, increase profitability, and stabilize food supply chains. This project also promotes domestic biomanufacturing and supports national goals to reduce reliance on imported agrochemicals, enhance food system resilience, and boost economic competitiveness. U.S. soybean production supports over $24 billion in exports and more than 2.5 million on-farm jobs, making protection of this sector a key national priority. This approach provides a scalable alternative to chemical pesticides, delivering long-term benefits for farmers, and consumers while advancing scientific and technological understanding of microbial solutions in agriculture. The proposed project seeks to translate an innovative RNA interference delivery technology from laboratory proof-of-concept