Epilepsy care primarily involves periodic visits to a neurology clinic for assessment and refinement of medications. A key gap in care is the inability to robustly monitor seizure activity outside of the clinic. Currently available wearable devices include wrist-based seizure detection devices that cannot record brain activity and suffer from poor sensitivity. At-home brain recordings with bulky full-scalp electroencephalography (EEG) caps are not practical for chronic use. To meet these challenges, this project is developing a wireless ear-based wearable, or “earable,” for monitoring neural activity using EEG electrodes behind each ear. The familiar form factor, similar to commercial earphones, will be more compatible with use during activities of daily living and can reduce the stigma that often accompanies wearable medical devices. The earable will feature a state-of-the-art custom integrated circuit with programmable artificial intelligence (AI) to infer seizure activity from the ear EEG signals. It will provide low-power wireless integration with a mobile app to alert the user and caregivers when seizure events are occurring or likely to occur. Access to remote seizure monitoring could improve refinement of medication while decreasing health care costs by requiring fewer in-person visits to the neurology clinic. A promising recent approach to epilepsy monitoring is to use ear-based wearables due to their access to EEG signals and unobtrusive form factor. It has been