I-Corps: Translation Potential of a Regenerative Medicine Platform to Address Peripheral Neuropathy

NSF Award Search · 01002526DB NSF RESEARCH & RELATED ACTIVIT · $50,000 · view on nsf.gov ↗

Abstract

This I-Corps project examines on the commercial potential of a novel regenerative medicine platform designed to address peripheral neuropathy, a debilitating condition affecting millions of individuals in the United States and world-wide. The project centers on two core innovations: lab-grown human nerve cells and a new therapeutic compound. The human nerve cells serve as a critical research tool for scientists and pharmaceutical developers to study nerve function and test potential treatments. The therapeutic compound under development is designed to protect and repair damaged nerves, offering hope for peripheral neuropathy patients who have few disease-modifying treatment options. By enabling more precise research and offering a new clinical pathway, this project supports public health, scientific progress, and future economic benefits through potential drug development and reduced healthcare burden. This I-Corps project utilizes experiential learning coupled with a first-hand investigation of the industry ecosystem to assess the translation potential of the technology. This solution is based on the development of human pluripotent stem cell-derived peripheral neurons, including sensory, sympathetic, and parasympathetic subtypes, and a first-in-class small molecule designed to protect peripheral neurons, prevent neuronal degeneration and promote axon regeneration. The neurons offer biological fidelity for preclinical research, enabling disease modeling and high-throughpu

Key facts

NSF award ID
2531097
Awardee
University of Georgia Research Foundation Inc (GA)
SAM.gov UEI
NMJHD63STRC5
PI
Nadja Zeltner
Primary program
01002526DB NSF RESEARCH & RELATED ACTIVIT
All programs
CHEMISTRY OF LIFE PROCESSES
Estimated total
$50,000
Funds obligated
$50,000
Transaction type
Standard Grant
Period
09/15/2025 → 08/31/2026