This award supports research that focuses on the development of Human-centric AI for Reconfigurable Manufacturing Operation and desigN sYnthesis (HARMONY) to harmonize human workers with increasingly autonomous resources. Emerging technologies, such as automated guided vehicles, mobile manipulators, collaborative and reconfigurable robots, offer new opportunities to address persistent challenges like machine breakdowns, material shortages, and demand fluctuations through dynamic reconfiguration of hardware, software, and logistics. However, fully realizing these benefits requires advanced analytical and programming skills to orchestrate multiple autonomous resources while meeting multi-facet performance targets and operational constraints. While generative artificial intelligence (GenAI) offers an intuitive interface for human-autonomy collaboration, its current application in manufacturing is limited by a lack of domain-specific knowledge. This project seeks to create preference-aligned decision options that humans can explore, select, and refine through low-barrier, multimodal interfaces. The project looks to also include an educational program featuring an innovative curriculum in AI and digital manufacturing, hands-on K–12 engagement and professional development opportunities delivered via workshops, webinars, industry partnerships, and Smart Learning Factories. Successful implementation of HARMONY has the potential to transform manufacturing systems to incorporate autono