I-Corps: Translation Potential of a Dynamic Quantitative Phase Microscopy Solution for Cost-effective, Noninvasive Imaging Systems

NSF Award Search · 01002526DB NSF RESEARCH & RELATED ACTIVIT · $50,000 · view on nsf.gov ↗

Abstract

This I-Corps project investigates the commercial potential of an optical microscopy technology that enables real-time, label-free imaging of biological samples with high accuracy. Traditional imaging systems that measure cell morphology and dynamic behavior are often prohibitively expensive, limiting access to advanced imaging tools. This solution addresses the need across biological research and medical diagnostics for cost-effective, noninvasive imaging systems. By integrating the technology with conventional microscopes, the solution reduces both acquisition and operational costs, expanding usage to smaller laboratories, clinics, and educational settings. This technology has potential applications in disease diagnosis and cellular biology, offering a more affordable approach to visualize and analyze nanoscale structures. This I-Corps project utilizes experiential learning coupled with a first-hand investigation of the industry ecosystem to assess the translation potential of the technology. This solution is based on the development of a compact, low-cost optical attachment that transforms existing microscopes into dynamic quantitative phase imaging systems capable of real-time, label-free, four-dimensional imaging. The system leverages inexpensive liquid crystal materials and custom-designed optics to achieve nanoscale precision in measuring cellular morphology. Unlike conventional systems that require costly optical components and sample staining, this approach preser

Key facts

NSF award ID
2534713
Awardee
University of North Carolina at Charlotte (NC)
SAM.gov UEI
JB33DT84JNA5
PI
Rosario Porras-Aguilar
Primary program
01002526DB NSF RESEARCH & RELATED ACTIVIT
All programs
Instr Rsrch,Metro&Std NanTech
Estimated total
$50,000
Funds obligated
$50,000
Transaction type
Standard Grant
Period
09/15/2025 → 08/31/2026