Abstract: U.S. Engagement and Leadership in the International Science Council The International Science Council (ISC) is the world’s leading international organization dedicated to advancing science, coordinating scientific priorities across borders, setting global standards, and informing science-based policymaking. The National Academy of Sciences (NAS), a founding member and the official U.S. adhering body to the ISC, represents U.S. science on this influential global platform. In an increasingly competitive and geopolitically complex landscape, this initiative reimagines U.S. global science leadership. It aims to ensure that NSF-supported researchers not only engage internationally but help shape the global science agenda. Through ISC, U.S. researchers will gain access to coordinated multinational initiatives, infrastructure, and scientific communities focused on advancing frontier research in areas such as artificial intelligence, quantum science, biotechnology, and translational research—fields critical to national priorities. The initiative also contributes to NSF’s mission by fostering a globally engaged, internationally competitive scientific workforce. It provides a foundational platform that U.S. institutions can leverage to build long-term scientific collaborations, promote innovation, and support U.S. economic growth and national security. Moreover, engagement with like-minded organizations within the ISC is critical to ensuring that core values—such as scient