Chronic stress during pregnancy is a serious and often underestimated threat to maternal and fetal health, linked to complications such as preeclampsia, preterm birth, and low birth weight. Unfortunately, current methods for monitoring stress in pregnant women are inadequate: questionnaires provide only subjective, infrequent data, lab tests are invasive and sporadic, and existing wearable devices capture only general physiological signals that are easily confounded by other factors. This project aims to fill that gap by creating a novel wearable tool for comprehensive stress monitoring. The device will continuously track both physiological stress indicators (e.g., heart rate variability) and molecular stress biomarkers (e.g., hormones and inflammatory markers) in real time. By enabling early and accurate detection of harmful stress levels, this project’s goal will allow timely interventions to protect maternal and fetal health. In doing so, it aligns with NSF’s mission by promoting scientific progress, advancing national health and welfare, and fostering interdisciplinary training. The project main objective is to develop an innovative wearable research platform that integrates novel molecular sensors with physiological sensors to enable comprehensive stress assessment during pregnancy. The team will create new electrically regenerable molecular sensors that can repeatedly detect multiple key stress biomarkers (e.g., cortisol and inflammatory cytokines) in in