Considering the widespread deployment of machine-learning hardware in myriads of modern-life applications, ensuring its reliable and safe operation is crucial to advance the national prosperity and welfare and to secure the national defense. While software and/or digital hardware implementations of neural networks currently enjoy the lion’s share of the market, a number of emerging realities are necessitating the development and deployment of analog neural networks. Specifically, the exponential growth of sensory data from world-machine interfaces, known as the analog data deluge, along with the area, power consumption and response-time constraints of distributed edge-computing systems, necessitate autonomous sensing, perception, reasoning and rapid action. While analog neural-network implementations promise to deliver this ability, their robustness and reliability are susceptible to parametric differences introduced by manufacturing process variation, operational conditions variation, as well as silicon aging. Accordingly, this project seeks to enable robust and resilient operation of analog neural networks and the applications wherein they are deployed, as well as to educate the next generation of engineers on the risks and remedies of using analog machine-learning hardware. At a technical level, this project combines state-of-the-art methods for designing, testing, and calibrating analog integrating circuits, with advanced concepts from training machine-learning models,