Physics-based forecasts of seismic hazard from future earthquakes are important for developing plans for land use, building codes, transportation and communication infrastructure, power and water systems, and many other aspects that are integral to society. The Quakeworx framework is a new multi-disciplinary collaboration to enable a wide community of users to access state-of-the-art physics-based models of rupture forecasts, further improve existing tools, and validate model results. Quakeworx also helps advance the science of rupture forecasts, obtain new insights on earthquake physics, improve seismic hazard estimates, and create new opportunities for STEM education and engagement. Quakeworx enables rapid immersion of students, post-docs, and early career scientists with state-of-the-art simulation and analysis tools that aid in modernizing education and training in earthquake physics, computational modeling, software engineering, and related fields. The project contributes to the national interest by supporting a more resilient society with improved capabilities for forecasting earthquakes and assessing seismic hazard, which are foundational for mitigation of seismic risk, contributing to STEM workforce development, and facilitating translation of results to the society at large. A core element of Quakeworx is a new science gateway, which provides access to state-of-the-art methods that combine novel physics-based modeling frameworks with standardized pipelines for sim