{"cik":"0001636282","ticker":"SYRE","name":"Spyre Therapeutics, Inc.","sic_code":"2834","sic_description":"Pharmaceutical Preparations","exchange":"Nasdaq","state_of_incorporation":"DE","fiscal_year_end":"1231","first_filing_date":"2026-05-08","last_filing_date":"2026-09-08","url":"/sec/cik-0001636282","insider_summary":{"total_transactions":73,"unique_insiders":10,"latest_transaction":"2026-10-01"},"recent_filings":[{"accession_number":"0001104659-26-115087","form_type":"SCHEDULE 13D/A","form_type_family":"other","doc_date":"2026-10-09","title":"SCHEDULE 13D/A — Spyre Therapeutics, Inc. — 2026-10-09","url_slug":"/sec/cik-0001636282/schedule-13d-a/0001104659-26-115087","edgar_url":"https://www.sec.gov/Archives/edgar/data/1636282/0001104659-26-115087-index.html"},{"accession_number":"0001628280-26-065291","form_type":"8-K","form_type_family":"current","doc_date":"2026-10-07","title":"8-K — Spyre Therapeutics, Inc. — 2026-10-07","url_slug":"/sec/cik-0001636282/8-k/0001628280-26-065291","edgar_url":"https://www.sec.gov/Archives/edgar/data/1636282/0001628280-26-065291-index.html"},{"accession_number":"0001628280-26-065249","form_type":"424B5","form_type_family":"registration","doc_date":"2026-10-06","title":"424B5 — Spyre Therapeutics, Inc. — 2026-10-06","url_slug":"/sec/cik-0001636282/424b5/0001628280-26-065249","edgar_url":"https://www.sec.gov/Archives/edgar/data/1636282/0001628280-26-065249-index.html"},{"accession_number":"0001628280-26-064924","form_type":"424B5","form_type_family":"registration","doc_date":"2026-10-05","title":"424B5 — Spyre Therapeutics, Inc. — 2026-10-05","url_slug":"/sec/cik-0001636282/424b5/0001628280-26-064924","edgar_url":"https://www.sec.gov/Archives/edgar/data/1636282/0001628280-26-064924-index.html"},{"accession_number":"0001636282-26-000119","form_type":"4","form_type_family":"insider","doc_date":"2026-10-02","title":"4 — Spyre Therapeutics, Inc. — 2026-10-02","url_slug":"/sec/cik-0001636282/4/0001636282-26-000119","edgar_url":"https://www.sec.gov/Archives/edgar/data/1636282/0001636282-26-000119-index.html"},{"accession_number":"0001636282-26-000118","form_type":"4","form_type_family":"insider","doc_date":"2026-10-02","title":"4 — Spyre Therapeutics, Inc. — 2026-10-02","url_slug":"/sec/cik-0001636282/4/0001636282-26-000118","edgar_url":"https://www.sec.gov/Archives/edgar/data/1636282/0001636282-26-000118-index.html"},{"accession_number":"0001636282-26-000117","form_type":"4","form_type_family":"insider","doc_date":"2026-10-02","title":"4 — Spyre Therapeutics, Inc. — 2026-10-02","url_slug":"/sec/cik-0001636282/4/0001636282-26-000117","edgar_url":"https://www.sec.gov/Archives/edgar/data/1636282/0001636282-26-000117-index.html"},{"accession_number":"0001104659-26-112828","form_type":"SCHEDULE 13G","form_type_family":"other","doc_date":"2026-10-01","title":"SCHEDULE 13G — Spyre Therapeutics, Inc. — 2026-10-01","url_slug":"/sec/cik-0001636282/schedule-13g/0001104659-26-112828","edgar_url":"https://www.sec.gov/Archives/edgar/data/1636282/0001104659-26-112828-index.html"},{"accession_number":"0001950047-26-009978","form_type":"144","form_type_family":"other","doc_date":"2026-10-01","title":"144 — Spyre Therapeutics, Inc. — 2026-10-01","url_slug":"/sec/cik-0001636282/144/0001950047-26-009978","edgar_url":"https://www.sec.gov/Archives/edgar/data/1636282/0001950047-26-009978-index.html"},{"accession_number":"0001950047-26-009971","form_type":"144","form_type_family":"other","doc_date":"2026-10-01","title":"144 — Spyre Therapeutics, Inc. — 2026-10-01","url_slug":"/sec/cik-0001636282/144/0001950047-26-009971","edgar_url":"https://www.sec.gov/Archives/edgar/data/1636282/0001950047-26-009971-index.html"},{"accession_number":"0001950047-26-009876","form_type":"144","form_type_family":"other","doc_date":"2026-09-30","title":"144 — Spyre Therapeutics, Inc. — 2026-09-30","url_slug":"/sec/cik-0001636282/144/0001950047-26-009876","edgar_url":"https://www.sec.gov/Archives/edgar/data/1636282/0001950047-26-009876-index.html"},{"accession_number":"0001636282-26-000113","form_type":"8-K","form_type_family":"current","doc_date":"2026-09-08","title":"8-K — Spyre Therapeutics, Inc. — 2026-09-08","url_slug":"/sec/cik-0001636282/8-k/0001636282-26-000113","edgar_url":"https://www.sec.gov/Archives/edgar/data/1636282/0001636282-26-000113-index.html"},{"accession_number":"0001636282-26-000111","form_type":"4","form_type_family":"insider","doc_date":"2026-09-03","title":"4 — Spyre Therapeutics, Inc. — 2026-09-03","url_slug":"/sec/cik-0001636282/4/0001636282-26-000111","edgar_url":"https://www.sec.gov/Archives/edgar/data/1636282/0001636282-26-000111-index.html"},{"accession_number":"0001636282-26-000109","form_type":"4","form_type_family":"insider","doc_date":"2026-09-03","title":"4 — Spyre Therapeutics, Inc. — 2026-09-03","url_slug":"/sec/cik-0001636282/4/0001636282-26-000109","edgar_url":"https://www.sec.gov/Archives/edgar/data/1636282/0001636282-26-000109-index.html"},{"accession_number":"0001636282-26-000107","form_type":"4","form_type_family":"insider","doc_date":"2026-09-03","title":"4 — Spyre Therapeutics, Inc. — 2026-09-03","url_slug":"/sec/cik-0001636282/4/0001636282-26-000107","edgar_url":"https://www.sec.gov/Archives/edgar/data/1636282/0001636282-26-000107-index.html"},{"accession_number":"0001950047-26-008970","form_type":"144","form_type_family":"other","doc_date":"2026-09-01","title":"144 — Spyre Therapeutics, Inc. — 2026-09-01","url_slug":"/sec/cik-0001636282/144/0001950047-26-008970","edgar_url":"https://www.sec.gov/Archives/edgar/data/1636282/0001950047-26-008970-index.html"},{"accession_number":"0001636282-26-000105","form_type":"8-K","form_type_family":"current","doc_date":"2026-08-25","title":"8-K — Spyre Therapeutics, Inc. — 2026-08-25","url_slug":"/sec/cik-0001636282/8-k/0001636282-26-000105","edgar_url":"https://www.sec.gov/Archives/edgar/data/1636282/0001636282-26-000105-index.html"},{"accession_number":"0001636282-26-000102","form_type":"4","form_type_family":"insider","doc_date":"2026-08-10","title":"4 — Spyre Therapeutics, Inc. — 2026-08-10","url_slug":"/sec/cik-0001636282/4/0001636282-26-000102","edgar_url":"https://www.sec.gov/Archives/edgar/data/1636282/0001636282-26-000102-index.html"},{"accession_number":"0001950047-26-007821","form_type":"144","form_type_family":"other","doc_date":"2026-08-07","title":"144 — Spyre Therapeutics, Inc. — 2026-08-07","url_slug":"/sec/cik-0001636282/144/0001950047-26-007821","edgar_url":"https://www.sec.gov/Archives/edgar/data/1636282/0001950047-26-007821-index.html"},{"accession_number":"0001950047-26-007819","form_type":"144","form_type_family":"other","doc_date":"2026-08-07","title":"144 — Spyre Therapeutics, Inc. — 2026-08-07","url_slug":"/sec/cik-0001636282/144/0001950047-26-007819","edgar_url":"https://www.sec.gov/Archives/edgar/data/1636282/0001950047-26-007819-index.html"},{"accession_number":"0001636282-26-000100","form_type":"4","form_type_family":"insider","doc_date":"2026-08-05","title":"4 — Spyre Therapeutics, Inc. — 2026-08-05","url_slug":"/sec/cik-0001636282/4/0001636282-26-000100","edgar_url":"https://www.sec.gov/Archives/edgar/data/1636282/0001636282-26-000100-index.html"},{"accession_number":"0001636282-26-000099","form_type":"4","form_type_family":"insider","doc_date":"2026-08-05","title":"4 — Spyre Therapeutics, Inc. — 2026-08-05","url_slug":"/sec/cik-0001636282/4/0001636282-26-000099","edgar_url":"https://www.sec.gov/Archives/edgar/data/1636282/0001636282-26-000099-index.html"},{"accession_number":"0001636282-26-000098","form_type":"8-K","form_type_family":"current","doc_date":"2026-08-04","title":"8-K — Spyre Therapeutics, Inc. — 2026-08-04","url_slug":"/sec/cik-0001636282/8-k/0001636282-26-000098","edgar_url":"https://www.sec.gov/Archives/edgar/data/1636282/0001636282-26-000098-index.html"},{"accession_number":"0001636282-26-000096","form_type":"10-Q","form_type_family":"quarterly","doc_date":"2026-08-04","title":"10-Q — Spyre Therapeutics, Inc. — 2026-08-04","url_slug":"/sec/cik-0001636282/10-q/0001636282-26-000096","edgar_url":"https://www.sec.gov/Archives/edgar/data/1636282/0001636282-26-000096-index.html"},{"accession_number":"0001950047-26-007571","form_type":"144","form_type_family":"other","doc_date":"2026-08-03","title":"144 — Spyre Therapeutics, Inc. — 2026-08-03","url_slug":"/sec/cik-0001636282/144/0001950047-26-007571","edgar_url":"https://www.sec.gov/Archives/edgar/data/1636282/0001950047-26-007571-index.html"}],"related_endpoints":{"profile":"/sec/SYRE/profile","timeline":"/sec/SYRE/timeline","peers":"/sec/SYRE/peers","insider_pulse":"/sec/SYRE/insider-pulse","insider_summary":"/sec/SYRE/insider-summary","insider_transactions":"/sec/SYRE/insider-transactions","form144":"/sec/SYRE/form144","holdings_as_filer":"/sec/SYRE/holdings","financial_facts":"/sec/SYRE/financial-facts","derivatives":"/sec/SYRE/derivatives","officers":"/sec/SYRE/officers","insider_network":"/sec/SYRE/insider-network","risk_flags":"/sec/SYRE/risk-flags","filings":"/sec/SYRE/filings","cross_topic_dossier":"/api/v1/dossier?ticker=SYRE"}}