Testing Blinatumomab With or Without Revumenib in Patients With B-cell Acute Lymphoblastic Leukemia With a Genetic Change Requiring More Treatment

NCT07636564 · clinicaltrials.gov ↗

PHASE2

Phase

NOT_YET_RECRUITING

Status

90

Enrollment

NETWORK

Sponsor class

Conditions

Acute Leukemia of Ambiguous Lineage
B Acute Lymphoblastic Leukemia
B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative
T Acute Lymphoblastic Leukemia

Interventions

PROCEDURE: Biospecimen Collection
BIOLOGICAL: Blinatumomab
PROCEDURE: Bone Marrow Aspiration
PROCEDURE: Bone Marrow Biopsy
DRUG: Calaspargase Pegol
PROCEDURE: Chest Radiography
PROCEDURE: Computed Tomography
DRUG: Cyclophosphamide
DRUG: Cytarabine
DRUG: Daunorubicin Hydrochloride
DRUG: Dexamethasone
DRUG: Doxorubicin
PROCEDURE: Echocardiography Test
DRUG: Leucovorin Calcium
DRUG: Mercaptopurine
DRUG: Methotrexate
PROCEDURE: Multigated Acquisition Scan
PROCEDURE: Positron Emission Tomography
DRUG: Revumenib
DRUG: Thioguanine

Sponsor

SWOG Cancer Research Network

Collaborators

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